• Department of Neurology, Children’s Hospital of Soochow University(Jiangsu Suzhou 215025, China;
TANG Jihong, Email: tjhzsh@126.com
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Objective In order to evaluate the efficacy, safety and tolerability of adjunctive perampanel in children with refractory epilepsy. Methods This study collected medical records of 34 children with refractory epilepsy, who were admitted to Children’s Hospital of Soochow University from January 2020 to January 2021. By comparing the baseline status with the status at 4, 8, 12, 24, 36, and 48 weeks of follow-up, the efficacy and adverse reactions of perampanel were evaluated. Results The mean age of the patients treated with perampanel was 8.1±4.1 years. The male-to-female ratio was 1: 1. After the addition of perampanel, the average responder rate at the 4th, 8th, 12th, 24th, 36th, 48th weeks were 37.5%, 46.7%, 50.0%, 47.4%, 53.8%, 42.9%. The adverse events were reported by 32.4%, and the retention rate was 88.2%. Conclusions Perampanel has good efficacy, safety and tolerability in the treatment of refractory epilepsy. Moreover, personalized treatment and better baseline seizure control may increase the effectiveness and retention rate of perampanel.

Citation: CHU Sijia, TANG Jihong, LI Yan, ZHANG Bingbing, XIAO Xiao, WANG Manli. Efficacy and safety of adjunctive perampanel in children with refractory epilepsy. Journal of Epilepsy, 2021, 7(5): 385-391. doi: 10.7507/2096-0247.20210062 Copy

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