Research progress on choroidal layer changes in eyes with retinal vein occlusion_Chinese Journal of Ocular Fundus Diseases

Authors：

Liu Chenxing ^1,2 , Chen Ziyang ³ , Ye Zhaoda ² , Chen Sheng ² ,  Hu Yanhong ²

1. Graduate School, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China;
2. Department of Ophthalmology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China;
3. Chinese Medicine Clinnic, Fujian Academy of Chinese Medical Sciences, Fuzhou 350003, China;

Corresponding author：

Hu Yanhong, Email: 12212022@163.com

Keywords：

Retinal vein occlusion; Choroidal thickness; Choroidal blood flow; Optical coherence tomography; Review

DOI：

10.3760/cma.j.cn511434-20241008-00370

Video：

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Retinal vein occlusion (RVO) is a serious retinal vascular disease, often accompanied by systemic cardiovascular and cerebrovascular diseases, the eye changes include macular edema, retinal ischemia, and even neovascularization, etc. As a common chronic disease of the fundus, it seriously affects patients' vision and quality of life. With the development of optical coherence tomography, the role of choroid in the occurrence and development of RVO has become a research hotspot. The research on the changes of the choroid layer of the eye with RVO has expanded from a simple two-dimensional thickness analysis to a more comprehensive multidimensional observation index such as three-dimensional volume, blood flow density and velocity. In addition, some cutting-edge research combines artificial intelligence algorithm techniques to improve the accuracy and depth of analysis. In the future, it is still necessary to further improve the data of the choroid layer of the eye with RVO, enhance the overall understanding of RVO, and provide new ideas for clinical prevention and treatment of RVO.

Citation： Liu Chenxing, Chen Ziyang, Ye Zhaoda, Chen Sheng, Hu Yanhong. Research progress on choroidal layer changes in eyes with retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2025, 41(2): 150-155. doi: 10.3760/cma.j.cn511434-20241008-00370 Copy

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1.
2.
3. Fragiotta S, Scuderi L, Iodice CM, et al. Choroidal vasculature changes in age-related macular degeneration: from a molecular to a clinical perspective[J/OL]. Int J Mol Sci, 2022, 23(19): 12010[2022-10-09]. https://pubmed.ncbi.nlm.nih.gov/36233311/. DOI: 10.3390/ijms231912010.
4.
5. Brinks J, van Dijk EHC, Klaassen I, et al. Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease[J/OL]. Prog Retin Eye Res, 2022, 87: 100994[2021-07-17]. https://pubmed.ncbi.nlm.nih.gov/34280556/. DOI: 10.1016/j.preteyeres.2021.100994.
6. Zheng G, Li J, Zhou Y, et al. Outer retina and choroid as potential imaging markers for evaluation of neural impairment in early type 2 diabetic patients[J/OL]. Eur J Ophthalmol, 2024, 11: 11206721241258637(20124-06-11)[2024-10-08]. https://pubmed.ncbi.nlm.nih.gov/38862403/. DOI: 10.1177/11206721241258637. [published online ahead of print].
7.
8.
9. Akatsuka M, Sugiyama E. Precision at the bedside: practical efficacy of clockwise catheter torque for accurate tip positioning of peripherally inserted central catheters[J/OL]. Cureus, 2023, 15(12): e50766[2023-12-19]. https://pubmed.ncbi.nlm.nih.gov/38239529/. DOI: 10.7759/cureus.50766.
10.
11. Dhirachaikulpanich D, Li X, Porter LF, et al. Integrated microarray and RNAseq transcriptomic analysis of retinal pigment epithelium/choroid in age-related macular degeneration[J/OL]. Front Cell Dev Biol, 2020, 8: 808[2020-08-21]. https://pubmed.ncbi.nlm.nih.gov/32984320/. DOI: 10.3389/fcell.2020.00808.
12.
13. Almalki YE, Ali MU, Kallu KD, et al. Isolated convolutional-neural-network-based deep-feature extraction for brain tumor classification using shallow classifier[J/OL]. Diagnostics (Basel), 2022, 12(8): 1793[2022-07-24]. https://pubmed.ncbi.nlm.nih.gov/35892504/. DOI: 10.3390/diagnostics12081793.
14.
15.
16. Zhang J, Liu Q, Han X. Dynamic sub-route-based self-adaptive beam search Q-learning algorithm for traveling salesman problem[J/OL]. PLoS One, 2023, 18(3): e0283207[2023-04-21]. https://pubmed.ncbi.nlm.nih.gov/36943840/. DOI: 10.1371/journal.pone.0283207.
17.
18.
19. Śpiewak D, Witek K, Drzyzga Ł, et al. An analysis of optical coherence tomography angiography (OCT-A) perfusion density maps in patients treated for retinal vein occlusion with intravitreal Aflibercept[J/OL]. Diagnostics (Basel), 2023, 13(19): 3100[2023-09-29]. https://pubmed.ncbi.nlm.nih.gov/37835843/. DOI: 10.3390/diagnostics13193100.
20. Hwang BE, Kim M, Park YH. Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema[J/OL]. PLoS One, 2021, 16(10): e0258728[2021-10-21]. https://pubmed.ncbi.nlm.nih.gov/34673807/. DOI: 10.1371/journal.pone.0258728.
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22.
23. Loiudice P, Covello G, Figus M, et al. Choroidal vascularity index in central and branch retinal vein occlusion[J/OL]. J Clin Med, 2022, 11(16): 4756[2022-08-15]. https://pubmed.ncbi.nlm.nih.gov/36012996/. DOI: 10.3390/jcm11164756.
24. Kang HM, Choi JH, Koh HJ, et al. Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion[J/OL]. PLoS One, 2021, 16(8): e0255182[2021-08-20]. https://pubmed.ncbi.nlm.nih.gov/34415912/. DOI: 10.1371/journal.pone.0255182.
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30. Alis A, Guler Alis M. The effect of branch retinal vein occlusion on the vascular structure of the choroid[J/OL]. Photodiagnosis Photodyn Ther, 2022, 37: 102687[2021-12-17]. https://pubmed.ncbi.nlm.nih.gov/34923154/. DOI: 10.1016/j.pdpdt.2021.102687.
31.
32. Chen L, Yuan M, Sun L, et al. Three-dimensional analysis of choroidal vessels in the eyes of patients with unilateral BRVO[J/OL]. Front Med (Lausanne), 2022, 9: 854184[2022-04-05]. https://pubmed.ncbi.nlm.nih.gov/35479961/. DOI: 10.3389/fmed.2022.854184.
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39. Aljundi W, Gradinger F, Langenbucher A, et al. Choroidal thickness as a possible predictor of non-response to intravitreal bevacizumab for macular edema after retinal vein occlusion[J/OL]. Sci Rep, 2023, 13(1): 451[2023-01-09]. https://pubmed.ncbi.nlm.nih.gov/36624124/. DOI: 10.1038/s41598-023-27753-7.
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