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find Keyword "鼻窦炎" 13 results
  • Systematic Review of the Safety of Steroids for Chronic Sinusitis/Nasal Polyps and Allergic Rhinitis

    Objective To evaluate the safety of intranasal use of beclomethasone dipropionate, budesonide, fluticasone propionate and mometasone for adults and children with chronic sinusitis/nasal polyps and allergic rhinitis. Methods Randomized controlled trials were located. Study quality was evaluated by two researchers independently. RevMan 4.2 was used for meta-analysis. Results Seven RCTs involving 826 patients were included. Compared with placebo, local use of fluticasone proprionate in adults showed no statistically significant trend to increase incidence of acute sinusitis (OR 16.87, 95% CI 0.87 to 301.62), but no significant difference was seen for epistaxis (OR 7.76, 95% CI 0.38 to 157.14): 1 trial, 60 patients. In another trial, no cases of nasal atrophy were reported in either fluticasone or placebo groups. No significant differences were seen between local use ofbudesonide and placebo in adults for dryness of nasal mucosa (OR 3.38, 95%CI 0.66 to 17.18) and epistaxis (OR 2.20, 95%CI 0.39 to 12.32): 1 trial, 193 participantions. No significant difference was seen between budesonide and pollinex for headache (OR 1.71, 95%CI 0.52 to 5.62). No differences were seen between placebo and fluticasone propionate in children for epistaxis (OR 0.85, 95%CI 0.20 to 3.66), headache (OR 0.25, 95%CI 0.02 to 2.83), plasma cortisol concentration (OR 1.56, 95%CI 0.06 to 38.69) and dryness of nasal mucosa (OR 4.76, 95%CI 0.25 to 89.54). Beclomethasone dipropionate in children showed no statistical differences for dryness of nasal mucosa (OR 0.51, 95%CI 0.14 to 1.87), epistaxis (OR 0.68, 95%CI 0.26 to 1.73) and rhinitis (OR 0.47, 95%CI 0.04 to 5.36). No decrease of plasma cortisol concentration was detected in either group. Mometasone and placebo showed no significant differences in children for epistaxis (OR 1.57, 95%CI 0.41 to 5.95), rhinitis (OR 0.33, 95%CI 0.01 to 8.22) or headache (OR 0.33, 95%CI 0.01 to 8.22). Decrease of plasma cortisol concentration was not detected. Conclusions According to this systematic review, long term intranasal use of steroid for adults and children may be safe based on the two high quality, four moderate quality trials and one with b bias. High quality studies with larger sample sizes and in other languages are needed to provide ber evidence.

    Release date:2016-09-07 02:28 Export PDF Favorites Scan
  • Nasal Endoscopic Surgery for Non-invasive Fungal Sinusitis and Drug Therapy during the Perioperative Period

    目的 观察非侵袭性真菌性鼻窦炎鼻内镜手术治疗效果及围手术期治疗对疗效的影响。 方法 回顾性分析2008年6月-2010年12月诊治的86例非侵袭性真菌性鼻窦炎患者的临床特征,总结鼻内镜手术治疗效果及围手术期抗生素、黏液促排剂、鼻喷激素、鼻冲洗等综合治疗的作用。 结果 86例患者均一次治愈,随访1~3年,无复发;围手术期综合治疗有利于减少术中出血,减轻术后黏膜水肿、减少分泌物,缩短病程。 结论 鼻内镜下彻底清除病灶是非侵袭性真菌性鼻窦炎安全、有效的一种治疗方法;合理的围手术期综合治疗具有其积极的作用。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • Traditional Chinese Medicine in the Irrigation of Chronic Rhinosinusitis after Endoscopic Sinus Surgery: A Systematic Review

    Objective To evaluate the efficacy and safety of traditional Chinese medicine (TCM) in treating Chronic Rhinosinusitis (CRS) after Functional Endoscopic Sinus Surgery (FESS). Methods The following databases and periodicals such as PubMed (Jan. 1980 to Jan. 2009), MEDLINE (1980 to 2009), EBSCOhost (Jan. 1975 to Jan. 2009), CALIS (1984 to 2009), CNKI (1979 to 2007), VIP (1989 to 2009), CBM (1978 to 2009); Chinese Journal of Otorhinolaryngology Head and Neck Surgery (1990 to 2008), Journal of Clinical Otorhinolaryngology Head and Neck Surgery (1988 to 2008), Otorhinolaryngology Head and Neck Surgery (1990 to 2008), and Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine (1996 to 2008) were searched by computer and handwork for randomized controlled trials (RCTs) about TCM to treat CRS after ESS. The trial screening, quality assessment, and the data extraction of the included trials were conducted before performing statistical analyses by using RevMan 4.2.10 software. Results A total of 32 RCTs in three sub-groups in Chinese literatures were identified with meta-analyses in comparisons of the cure rate (OR=1.99, 95%CI 1.78 to 2.23), total effective rate (OR=2.66, 95%CI 2.20 to 3.22), degree I postoperative improvement rate (OR=2.22, 95%CI 1.60 to 3.06), total postoperative improvement rate (OR=8.77, 95%CI 1.09 to 70.64), postoperative clean time (OR=2.54, 95%CI 1.70 to 3.79), postoperative epithelization time (OR= –29.46, 95%CI –37.73 to –21.18), and mucociliary transport rate (OR=1.14, 95%CI 0.22 to 2.06). A total of 4 RCTs were meta-analyzed to evaluate the safety in comparisons of gastrointestinal reaction (OR=0.25, 95%CI 0.00 to 33.78) and local reaction (OR=0.03, 95%CI 0.01 to 0.12). Conclusion The current evidence shows TCM in treating CRS after ESS tends to improve the clinical efficacy and reduce the cure time without obvious adverse reaction. Due to the low methodological quality of included trials, more RCTs with high quality and large scale are required.

    Release date:2016-09-07 11:04 Export PDF Favorites Scan
  • Chronic rhinosinusitis and chronic obstructive pulmonary disease: a two-sample two-way Mendelian randomization study

    Objective To investigate the potential causal relationship between chronic rhinosinusitis (CRS) and chronic obstructive pulmonary disease (COPD) using a two-sample two-way Mendelian randomization (MR) approach. Methods In the forward study, single nucleotide polymorphisms (SNPs) closely associated with CRS were selected as instrumental variables from publicly available genome-wide association studies datasets, with COPD as the outcome variable; conversely, in the reverse study, SNPs closely associated with COPD were selected as instrumental variables, with CRS as the outcome variable. MR analysis was conducted using three regression models: inverse variance weighted (IVW), MR-Egger regression analysis, and weighted median (WME) to assess the causal relationship between CRS and COPD. Cochran’s Q statistic, MR-Egger intercept, MR-PRESSO, and “leave-one-out” methods were employed to test for heterogeneity and horizontal pleiotropy, thereby evaluating the stability and reliability of the MR results. Results A total of 14 SNPs closely associated with CRS were included in the forward study; the IVW-fixed effects analysis indicated that CRS may increase the risk of developing COPD [odds ratio=1.003, 95% confidence interval (1.002, 1.004), P<0.001], which was confirmed by the WME method, while the MR-Egger regression method did not show a causal link between CRS and COPD. Heterogeneity test (IVW result: Cochran’s Q=7.910, P=0.849; MR-Egger regression result: Cochran’s Q=7.450, P=0.827), MR-Egger intercept method (P=0.510), MR-PRESSO test (P=0.917), and “leave-one-out” method showed that the MR analysis results were reliable. In the reverse study, a total of 12 SNPs related to COPD were included as instrumental variables; MR analysis did not support the notion that COPD would increase the risk of CRS (P>0.05). Heterogeneity test (IVW result: Cochran’s Q=5.947, P=0.877; MR-Egger regression result: Cochran’s Q=5.937, P=0.821), MR-Egger intercept method (P=0.921), MR-PRESSO test (P=0.875), and “leave-one-out” analysis method showed that the MR analysis results were reliable. Conclusions There is a potential causal association between CRS and COPD, and CRS may increase the risk of developing COPD. But there is no evidence to suggest that COPD increases the risk of CRS.

    Release date:2024-10-25 01:48 Export PDF Favorites Scan
  • 儿童复发性鼻窦炎伴鼻息肉再次内镜手术的疗效分析

    目的探讨并分析儿童慢性鼻窦炎伴鼻息肉患者再次内镜手术的部位以及评价手术治疗的疗效。 方法回顾性分析 1998 年 1 月-2009 年 10 月住院治疗的 88 例儿童慢性鼻窦炎伴鼻息肉患者的临床资料,所有患儿均经鼻内镜手术治疗,对于复发鼻息肉的 14 例患儿再次手术术后随访 1 年以上,并采用视觉模拟评分(VAS)和 Lund-Kennedy 鼻内镜检查评分评价客观感受,同时观察临床治疗疗效。 结果14 例患儿术前 VAS 评分为(7.4±1.3)分,术后 1 年 VAS 评分为(0.8±1.2)分,差异有统计学意义(t=10.462, P<0.001);术前 Lund-Kennedy评 分 为(10.0±2.1)分,术 后 1 年 Lund-Kennedy 评 分 为(1.6±1.4)分,差 异 有 统 计 学 意 义(t=8.451, P<0.001)。5 例复发于筛窦(4 例双侧, 1 例单侧), 4 例复发于上颌窦口(2 例双侧, 2 例单侧), 5 例复发于上颌窦内(均为单侧)。14 例复发鼻息肉患儿中,治愈 12 例(85.7%),有效 2 例(14.3%),总有效率为 100%。无患儿发生严重并发症。 结论儿童复发鼻息肉的好发部位为筛窦和上颌窦,再次手术治疗疗效满意。

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  • Multi-Centre Randomized Controlled Trial of Bi Yuan Shu Liquid on Patients with Chronic Nasal Sinusitis or Nasal Polyp after Endosoopic Sinus Surgery

    Objective To study the effect of Bi Yuan Shu Liquid on melioration of clinical symptoms and signs of chronic nasal sinusitis or nasal polyp patients after Functional Endosoopic Sinus Surgery (FESS), and discuss the effectiveness of Chinese composite medicine in the overall treatment after FESS. Methods A total of 340 patients were randomly allocated to treatment group (n =170) and control group (n =170) according to simple randomization procedure. Patients in treatment group were administrated with quinolone, steroid, and Bi Yuan Shu Liquid, which were compared with those in control group who were given quinolone and steroid. Results The apparent effect of treatment group and control group were 30.6% and 42.4% of 42.4% of ITT. Results by Wilcoxon signed rank test indicated that there was a statistically significant difference. Conclusions Bi Yuan Shu Liquid may improve the effectiveness of sinus surgery, reduce the time course of antibiotics and hormones, and with out toxicity and side-effect.

    Release date:2016-09-07 02:28 Export PDF Favorites Scan
  • Therapeulvd Experience of 11 Cases of Noninvasive Fungal Rhino-sinusitis

    目的:探讨慢性非侵袭性真菌性鼻窦炎(NIFS)的治疗要点。方法:分析11 例NIFS 患者,全部施行鼻内镜手术,术后定期随访。结果:术后随访2年,全部治愈。结论:以鼻内镜手术治疗为主的综合治疗,疗效好,复发率低。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • Kartagener 综合征四例报告并文献复习

    目的探讨 Kartagener 综合征的临床特点,提高该病的诊治水平。方法回顾本院呼吸内科收治的 4 例 Kartagener 综合征患者的临床资料,综合复习相关文献后进行分析。结果4 例 Kartagener 综合征中,男 3 例,女 1 例,年龄 24~51 岁。1 例父母为表兄妹近亲结婚。患者均因咳嗽、咳痰,伴或不伴咯血痰、胸闷、气促、喘息、浮肿、发热等症状就诊。1 例在外院确诊 Kartagener 综合征、肺源性心脏病,余 3 例 CT 影像等检查提示存在内脏转位、支气管扩张、鼻窦炎三联征,入院后确诊 Kartagener 综合征。4 例均给抗感染、祛痰、分泌物引流治疗,合并肺源性心脏病者予以无创呼吸机辅助通气、抗心力衰竭等治疗后,病情缓解出院。复习国内外文献,咳嗽、咳痰、咯血、气促是 Kartagener 综合征就诊的主要症状;预防感染、及时控制感染是治疗 Kartagener 综合征的关键。随着对 Kartagener 综合征的基因遗传学研究的深入,有望寻找到有效的办法以早期诊断,有效治疗,甚至减少发病。结论Kartagener 综合征是一种以内脏转位、支气管扩张、鼻窦炎为表现的罕见的先天遗传性疾病。提高临床医生对该病的认识,早期诊断,综合治疗,有效控制慢性气道炎症,是控制疾病进展、改善预后的有效方法。

    Release date:2019-07-19 02:21 Export PDF Favorites Scan
  • CT、MRI对霉菌性鼻窦炎的诊断价值

    目的:探讨CT、MRI对霉菌性鼻窦炎的诊断和鉴别诊断价值.方法:回顾性分析32例霉菌性鼻窦炎CT、MRI表现。结果:霉菌性鼻窦炎的CT表现主要为:①90.6%的病变内有高密度钙化影。大多呈斑点状,位于窦腔中央,与窦壁无关。②50.0%的窦壁存在骨质破坏,常见于上颌窦内侧壁,其特点是伴有窦壁骨质增生。霉菌性鼻窦炎的MRI表现为上颌窦病变中央大部分呈T1、T2低信号。结论:霉菌性鼻窦炎有较特征性的CT、MRI表现,CT对病灶内钙化显示较MRI更明确,而且经济,是首选的影像检查方法,MRI在评估病变窦腔外受累及与肿瘤鉴别方面优于CT。

    Release date:2016-09-08 10:00 Export PDF Favorites Scan
  • 罕见病黄甲综合征一例

    Release date:2019-01-23 01:20 Export PDF Favorites Scan
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